Pakistan will not bow to US pressure to step up its fight against militancy, its prime minister has said.
Yousuf Raza Gilani told a rare meeting of political and religious parties that relations between the two countries should be based on mutual respect.
He said that Pakistan's "national interests" should be respected.
Relations have hit new lows since the top US military officer said Pakistan was backing the Haqqani group in Afghanistan, a charge Pakistan rejects.
Washington wants Islamabad to sever links with the Haqqani group, which correspondents say has roots deep inside Pakistani territory.
US officials say they are close to deciding whether to label the group as a foreign terrorist organisation.
"Pakistan cannot be pressured to do more," Mr Gilani told the meeting in Rawalpindi.
"The blame game should end, and Pakistan's sensitive national interests should be respected," he said, in comments carried live on local television stations.
He said that Pakistan was united over any threat to its sovereignty.
Tensions between the two countries, which were already high, rose still further last week when the most senior US military officer, Adm Mike Mullen, made his accusations, calling the Haqqanis a "veritable arm" of Pakistan's spy agency.
The White House, however, made slightly more conciliatory noises on Wednesday.
Spokesman Jay Carney said he would not have used the same language as Adm Mullen, while Secretary of State Hillary Clinton said the two countries have to "work together".
